It might work but latency would be killer. If it’s not a huge pain to try it out it can’t hurt!
Windows 10 is getting a legit Linux kernel soon so it can do containers and other Linux-like things. So that’s kind of cool. I’d jump to Ubuntu in a heartbeat if it had the support for audio that Windows & MacOS does. The potential for super low latency and efficient file system handling is there and it’s way more tuneable than Windows. Maybe some haxOr can get OB running with Wine or something.
Virtualization and realtime requirements (= stable lowlevel timing for short audio buffers) won’t match up well. Especially when running under Windows.